RSS Nucleic Acids Research - current issue
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原站：http://nar.oxfordjournals.org
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“Nucleic Acids Research - current issue”的内容更新
累计：2876 篇（自 2008-12-24 起）
更新：约2篇/天，最后更新11 天前
Nucleic Acids Research - current issue
Nucleic Acids Research: VOLUME 40 ISSUE 3 2012
无... (11 天前)
Nucleic Acids Research - current issue
NTRFinder: a software tool to find nested tandem rep
we introduce the software tool ntrfinder to search for a complex repetitive structure in dna we call a nested tandem repeat (ntr). an ntr is a recurrence of two or more distinct tandem motifs interspersed with each other. we propose that ntrs can be used as phylogenetic and population markers. we have tested our algorithm on both real and simulated data... (11 天前)
Nucleic Acids Research - current issue
An iterative network partition algorithm for accurat
a key step in network analysis is to partition a complex network into dense modules. currently, modularity is one of the most popular benefit functions used to partition network modules. however, recent studies suggested that it has an inherent limitation in detecting dense network modules. in this study, we observed that despite the limitation, modular... (11 天前)
Nucleic Acids Research - current issue
A versatile element for gene addition in bacterial c
the increasing interest in genetic manipulation of bacterial host metabolic pathways for protein or small molecule production has led to a need to add new genes to a chromosome quickly and easily without leaving behind a selectable marker. the present report describes a vector and four-day procedure that enable site-specific chromosomal insertion of clo... (11 天前)
Nucleic Acids Research - current issue
Construction of repeat-free fluorescence in situ hyb
fish probes are generally made out of bac clones with genomic dna containing a variable amount of repetitive dna that will need to be removed or blocked for fish analysis. to generate repeat free (rf) probes without loss in genomic coverage, a random library is made from bac clones by whole-genome amplification (wga). libraries are denatured in the pres... (11 天前)
Nucleic Acids Research - current issue
Isolation of homozygous mutant mouse embryonic stem
obtaining random homozygous mutants in mammalian cells for forward genetic studies has always been problematic due to the diploid genome. with one mutation per cell, only one allele of an autosomal gene can be disrupted, and the resulting heterozygous mutant is unlikely to display a phenotype. in cells with a genetic background deficient for the bloom's... (11 天前)
Nucleic Acids Research - current issue
Sensitive RNA detection by combining three-way junct
recently, we developed a simple isothermal nucleic acid amplification reaction, primer generation-rolling circle amplification (pg-rca), to detect specific dna sequences with great sensitivity and large dynamic range. in this paper, we combined pg-rca with a three-way junction (3wj) formation, and detected specific rna molecules with high sensitivity an... (11 天前)
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