原站：http://neurophenomicslab.blogspot.com/

“On Our Minds at the Laboratory of Neurophenomics”的内容更新

累计：14 篇（自 2009-02-23 起）

更新：约5篇/年，最后更新209 天前

On Our Minds at the Laboratory of Neurophenomics

Psychiatric genetics: contextual cumulative combinat

classic genetics research in psychiatric disorders has provided an abundance of data but a paucity of insight. things will only get worse in terms of this ratio, as massive sequencing of genomes becomes routine. the reasons are four-fold. first, psychiatric disorders are genetically complex, with many (hundreds, if not thousands) genes involved. we first... (209 天前)

http://inezha.com/w/qq2w2xg

On Our Minds at the Laboratory of Neurophenomics

Clock Genes and Mood

"there can be no transforming of darkness into light and of apathy into movement without emotion" - carl jung after more than a decade of work on understanding mood, using the magnifying glass of severe mood dysregulation disorders such as bipolar disorder, our group has proposed and provided evidence for mood being related to levels of a... (231 天前)

http://inezha.com/w/20j5bxb

On Our Minds at the Laboratory of Neurophenomics

The Biomarkers Solution: How to Improve Pharma Drug

the drug discovery process is currently flawed at both pre-clinical and clinical levels. biomarkers are an emerging “bridge over troubled waters” between these two areas, and a solution for their respective ills.preclinically, gene expression networks, not single gene products, need to be targeted for comprehensive and successful treatment of diseases.... (311 天前)

http://inezha.com/w/8kuvjxm

On Our Minds at the Laboratory of Neurophenomics

Trend of the Year in 2011: Social connections, lower

isolation is a powerful stressor-in people, animals, and probably all the way to single cells. it is associated with higher anxiety, lower mood and lower cognition, and myriad health problems. isolation leads to uncertainty about safety, ability to thrive and ability to influence events. it is becoming more prevalent in modern societies, where social, fa... (311 天前)

http://inezha.com/w/o62nyxx

On Our Minds at the Laboratory of Neurophenomics

Increasing resilience to disease by increasing genom

it is becoming clear that dna mutations, epigenetic changes, and gene expression modulation are involved in medical disorders in general, and psychiatric disorders in particular. in addition to avoiding the offending environmental agents, what else can be done? a powerful approach in medicine is to increase resilience/immunity as a way to prevent/treat d... (311 天前)

http://inezha.com/w/jmjoux2

On Our Minds at the Laboratory of Neurophenomics

Suicidality: a form of transient psychosis

suicidality in a broad sense can be viewed as a self-deletion (apoptosis) of the organism due to a perception of suffering, being damaged, hopelessly/irreversibly so, and a burden to its extended kin. while there is an evolutionary rationale for such a mechanism and behavior to exist and persist in the population at large, in most cases an affective and ... (311 天前)

http://inezha.com/w/h4uyrwk

On Our Minds at the Laboratory of Neurophenomics

Alzheimer (and schizophrenia) are the result of stre

our speculative but data-informed view: alzheimer disease is a result of the cumulative combination of stresses on the brain in people who have increased neuronal plasticity, and reach a tipping point of neuronal fragility leading to apoptosis. in this view, amyloid, as well as tau, are symptoms, not causes of the neuronal deterioration. in fact, they ma... (311 天前)

http://inezha.com/w/gl242wn

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